Polθ-IN-11

Overview

Polθ-IN-11 is an orally active DNA polymerase θ ( Polθ ) ATPase inhibitor with an IC 50 of 4.3 nM against human targets. Polθ-IN-11 activates the cGAS-STING pathway. Polθ-IN-11 upregulates the expression of PD-L1 in HR-deficient cancer cells. Polθ-IN-11 acts synergistically with PARP inhibition in HR-deficient cancer cells and in vivo xenograft models. Polθ-IN-11 can be used in studies related to HR-deficient cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > STING | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > IKK

Product Information

• Catalog No.: HY-183748
• CAS No.: 3082173-75-6
• Molecular Formula: C24H18FN5O3Se
• Molecular Weight: 522.39
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source