WF-2421 is an aldose reductase inhibitor with an IC 50 of 0.03 μM against rabbit-derived aldose reductase . WF-2421 acts as a non-competitive inhibitor of aldose reductase using dl-glyceraldehyde as the substrate. WF-2421 can be used in the research of diabetic complications (cataract, neuropathy, retinopathy, nephropathy).
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