NCATS-SM1440

Overview

NCATS-SM1440 is a glycolysis inhibitor and metabolic regulator that targets LDHA and LDHB ( IC 50 =0.06 μM and 0.03 μM, respectively). Upon binding to LDHA, NCATS-SM1440 blocks the glycolysis pathway and reduces lactate production. NCATS-SM1440 drives the shift of pyruvate metabolism toward mitochondrial metabolism , effectively disrupting the dependence of cancer cells on aerobic glycolysis. NCATS-SM1440 can be widely used in research related to cancer , Ewing's sarcoma, and other related conditions.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Lactate Dehydrogenase

Product Information

• Catalog No.: HY-183858
• CAS No.: 1964516-59-3
• Molecular Formula: C30H22F2N4O4S3
• Molecular Weight: 636.71
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source