NPC-14695

Overview

NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a K d value of 15 nM for guinea pig M3, 60 nM for guinea pig M2 , and 25 nM for rabbit M1 . NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Muscle Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > mAChR

Product Information

• Catalog No.: HY-183932
• CAS No.: 146561-59-3
• Molecular Formula: C24H30N2O2
• Molecular Weight: 378.51
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source