USP7-IN-20

Overview

USP7-IN-20 is a highly selective USP7 inhibitor that binds allosterically to the allosteric pocket of USP7 in a non-competitive and reversible manner. USP7-IN-20 downregulates MDM2 protein levels and stabilizes p53 , thereby inducing p21 expression and enhancing the ubiquitin-dependent degradation of MDM2 . USP7-IN-20 effectively binds endogenous USP7 to inhibit cancer cell proliferation, and also induces apoptosis by promoting the cleavage of PARP and caspase 3 . USP7-IN-20 can be widely used in cancer-related basic and translational research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-183942
• CAS No.: 2196246-28-1
• Molecular Formula: C22H24BrN3O3S
• Molecular Weight: 490.41
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source