KRASG12D-IN-8

Overview

KRASG12D-IN-8 is an orally active KRAS G12D inhibitor, with a K d value of 0.003 nM for KRAS G12D and 0.024 nM for KRAS G12V . KRASG12D-IN-8 inhibits the activity of phosphorylated ERK in KRAS-mutated cells. KRASG12D-IN-8 induces tumor regression in ovarian cancer xenograft mouse models. KRASG12D-IN-8 can be used for the research of KRAS-mutated cancers.

Application

Products | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Ovarian Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-184010
• CAS No.: 3101973-42-3
• Molecular Formula: C35H37F3N6O4
• Molecular Weight: 662.70
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source