Cyclazosin

Overview

Cyclazosin is an α 1 D-adrenergic receptor antagonist and a partial agonist of CXCR4/ACKR3 . The pKi values of Cyclazosin for cloned human α 1 D , α 1 B and α 1 A adrenergic receptors are 9.28, 9.23 and 8.18, respectively. Cyclazosin induces β-arrestin recruitment in CXCR4 and ACKR3 with EC50 values of 16 μM and 10 μM, respectively, stimulates ERK1/2 phosphorylation, and induces receptor internalization. Cyclazosin potently inhibits CXCL12-induced chemotaxis of primary human aortic vascular smooth muscle cells. Cyclazosin alters MDMA-induced thermoregulatory responses in mice, converting monophasic hyperthermia to a biphasic pattern without affecting resting core body temperature. Cyclazosin can be used for diseases related to tumor metastasis, MDMA-induced hyperthermia and vasoconstriction.

Application

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Product Information

• Catalog No.: HY-184086
• CAS No.: 139953-73-4
• Molecular Formula: C23H27N5O4
• Molecular Weight: 437.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source