ATB1071 is a brain-penetrant and orally active p62/SQSTM1 activator. ATB1071 binds to the p62-ZZ domain, promotes PB1-dependent p62 self-polymerization, and activates p62-mediated mitophagy . ATB1071 can be used for the research of Leigh syndrome, cerebral ischemia-reperfusion injury [1] .
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