Pabgraminone C

Overview

Pabgraminone C (IM502) is a Fungal metabolite and PI3Kγ inhibitor with an IC 50 of 61.7 nM against PI3Kγ . Pabgraminone C shifts the STAT signaling pathway in cells from an immunosuppressive STAT3/STAT6 -dominant profile to an immunostimulatory STAT1/STAT2 -dominant profile, driving cells toward a pro-inflammatory phenotype. Pabgraminone C reprograms cells from an immunosuppressive state to an immunostimulatory state, reversing their suppressive effect on anti-tumor immunity. Pabgraminone C inhibits established tumor growth and metastasis across multiple cancer types. Pabgraminone C overcomes resistance to PD-1 checkpoint blockade strategies. Pabgraminone C can be used in research related to liver cancer , melanoma, and colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Melanoma | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Cancer Immunology | Products > Disease Areas > Immunotherapy for Melanoma | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > STAT | Products > Signaling Pathways > PD-1/PD-L1

Product Information

• Catalog No.: HY-184119
• CAS No.: 3061276-55-6
• Molecular Formula: C16H20O4
• Molecular Weight: 276.33
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source