HSP110-IN-1

Overview

HSP110-IN-1 is a HSP110 inhibitor. HSP110-IN-1 binds to HSP110 , inhibits the activity of STAT3 , and downregulates the expression of downstream genes VEGF , MMP7 and MMP9 . HSP110-IN-1 abrogates IL-6-induced epithelial-mesenchymal transition and inhibits the proliferation of colorectal cancer cells. HSP110-IN-1 remodels the tumor microenvironment by inducing a pro-inflammatory phenotype, regulates macrophages, induces PD-L1 expression, and enhances anti-PD-L1 antibody-mediated tumor regression. HSP110-IN-1 can be used in studies related to colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > MMP | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > HSP | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-184162
• CAS No.: 2991567-27-0
• Molecular Formula: C29H32N4O5
• Molecular Weight: 516.59
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source