W2A-28

Overview

W2A-28 is a daul modulator of class I HDAC s and Wnt/β-catenin . W2A-28 inhibits HDAC1 , 2 and 3 activities with IC 50 values of 512, 675, and 217 nM, respectively. W2A-28 shows selectivity over other HDACs and Sirtuin family members . W2A-28 activates Wnt/β-catenin signaling via reduced LRP6 degradation, enhances histone acetylation, suppresses tau phosphorylation, and reduces Aβ 40 and Aβ 42 levels . W2A-28 can be used for the research of Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Wnt | Products > Signaling Pathways > β-catenin | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-184177
• CAS No.: 2803203-72-5
• Molecular Formula: C14H14N4O2
• Molecular Weight: 270.29
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source