CAS-010

Overview

CAS-010 (CAS-13312-010) is a potent and selective USP28 inhibitor with an IC 50 of 2.2 nM against full-length USP28. CAS-010 acts as a ubiquitin-competitive inhibitor and shows higher selectivity over USP25 (IC 50 = 51 nM) and other USP family members, disrupting the 53BP1-USP28 interaction and suppressing p53-dependent transcription of CDKN1A (p21), MDM2 , and BAX . CAS-010 can be used for studying USP28-mediated DNA damage response and p53 signaling in cancer-related research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase

Product Information

• Catalog No.: HY-184244
• CAS No.: 3094094-17-1
• Molecular Formula: C26H32N4OS
• Molecular Weight: 448.62
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source