VCP/p97 IN-4

Overview

VCP/p97 IN-4 is a p97/VCP inhibitor (K d =14.99 μM) targeting the allosteric site of the D1-D2 domain. VCP/p97 IN-4 inhibits the ATPase activity of VCP/p97 in an ATP concentration-independent manner. VCP/p97 IN-4 induces apoptosis , autophagy , mitochondrial stress and mitochondrial membrane depolarization. VCP/p97 IN-4 inhibits the growth of patient-derived colorectal cancer organoids and exhibits in vivo efficacy in a colorectal cancer xenograft mouse model. VCP/p97 IN-4 can be used for the research of colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy

Product Information

• Catalog No.: HY-184291
• CAS No.: 3114314-82-5
• Molecular Formula: C28H29F2N3
• Molecular Weight: 445.55
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source