RN193

Overview

RN193 is a type II kinase inhibitor with a human PAK1 IC 50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1 , PAK2 , and PAK3 , and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1 , GSK3B , ULK1 , MELK , MAPK13 , BRAF , and STK10 , indicating binding and stabilization of these proteins. RN193 induces formation of PAK3 : PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Others | Products > Signaling Pathways > PAK

Product Information

• Catalog No.: HY-184447
• CAS No.: 3091508-49-2
• Molecular Formula: C30H32N6O3
• Molecular Weight: 524.61
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source