S27-1047

Overview

S27-1047 is a brain-penetrant, potent and selective BChE ( eq BChE IC 50 = 7.16 nM; h BChE IC 50 = 296.10 nM) inhibitor and Nrf2 activator. S27-1047 can directly bind Keap1, disrupt Keap1-Nrf2 interaction ( FP IC 50 = 36.87 nM), enhance antioxidant enzyme expression and activate the GSH-GPX4 axis to inhibit A β -induced ferroptosis . S27-1047 can protect against oxidative stress and neuroinflammation. S27-1047 can be used in Alzheimer's disease research .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Glutathione Peroxidase

Product Information

• Catalog No.: HY-184583
• CAS No.: 3121876-09-0
• Molecular Formula: C25H16F2N8O3
• Molecular Weight: 514.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source