VEGFR/PDGFR/CA II-IN-1

Overview

VEGFR/PDGFR/CA II-IN-1 is a VEGFR/PDGFR/CA II inhibitor. VEGFR/PDGFR/CA II-IN-1 potently inhibits VEGFR2 ( IC 50 = 62.66 nM), PDGFRα ( IC 50 = 18.65 nM), PDGFRβ ( IC 50 = 5.23 nM), and hCA II ( K i = 19.4 nM), with weaker activity against hCA I ( K i = 154.2 nM) and hCA IX ( K i = 121.0 nM). VEGFR/PDGFR/CA II-IN-1 exhibits potent antiproliferative activity in VEGFR2-BAF3 cells and robust inhibition of angiogenesis in human umbilical vein endothelial cells (HUVECs). VEGFR/PDGFR/CA II-IN-1 inhibits the formation of corneal neovascularization in rabbits through multiple signaling pathways, and significantly reduced intraocular pressure (IOP) in both acute and chronic glaucoma models. VEGFR/PDGFR/CA II-IN-1 can be used to study neovascular glaucoma (NVG).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Glaucoma | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > Carbonic Anhydrase

Product Information

• Catalog No.: HY-184656
• CAS No.: 3099422-14-4
• Molecular Formula: C36H35FN6O6S
• Molecular Weight: 698.76
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source