Tefludazine

Overview

Tefludazine is an orally active antagonist of dopamine D 2 receptor with an IC 50 of 8.8 nM and 5-HT 2 receptor with an IC 50 of 8.6 nM. Tefludazine moderately inhibits the uptake of dopamine, norepinephrine and serotonin in rat brain synaptosomes, with IC 50 values of 520 nM, 660 nM and 7000 nM, respectively . Tefludazine exhibits long-acting antipsychotic activity, lacks anticholinergic activity, shows Clozapine ( HY-14539 )-like effects at low doses and Haloperidol ( HY-14538 )-like effects at high doses. Tefludazine can be used for the research of psychotic disorders.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-184802
• CAS No.: 80273-79-6
• Molecular Formula: C22H24F4N2O
• Molecular Weight: 408.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source