W1307

Overview

W1307 is a selective STAT3 inhibitor with a K D value of 1.74 μM. W1307 inhibits STAT3 Tyr705 phosphorylation, disrupts STAT3 dimerization, and suppresses STAT3 transcriptional activity. W1307 downregulates the expression of STAT3 downstream targets c-Myc , Mcl-1 and Bcl-2 . W1307 transcriptionally inhibits SREBP1 and CPT2 expression to disrupt lipid homeostasis. W1307 shows potent anti-leukemic activity and synergizes with Cytarabine (Ara-C) ( HY-13605 ) to overcome chemoresistance in acute myeloid leukemia (AML).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Fatty Acid Synthase (FASN) | Products > Signaling Pathways > Carnitine Palmitoyltransferase (CPT) | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > STAT | Products > Signaling Pathways > c-Myc

Product Information

• Catalog No.: HY-184891
• CAS No.: 3028770-95-5
• Molecular Formula: C20H15N3O3
• Molecular Weight: 345.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source