GLyT2-IN-3

Overview

GLyT2-IN-3 is a potent GlyT2 inhibitor with a K D of 23.7 nM. GLyT2-IN-3 inhibits GlyT2 -mediated glycine uptake with an IC 50 of 19.4 nM. GLyT2-IN-3 shows broad-spectrum antinociceptive effects in three pain models, does not induce sedative effects or motor coordination impairment in mice, and exhibits favorable pharmacokinetic properties in rats with an oral bioavailability of 88.57%, GLyT2-IN-3 can be used for the study of neuropathic pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GlyT

Product Information

• Catalog No.: HY-184901
• CAS No.: 2789716-24-9
• Molecular Formula: C23H31N3O4
• Molecular Weight: 413.51
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source