(R)-HDAC-IN-102 is a HDAC2 inhibitor and the isomer of HDAC-IN-102 ( HY-185554 ). HDAC-IN-102 inhibits total HDAC with an IC 50 of 58 μM and exhibits partial subtype selectivity. Specifically, (R)-HDAC-IN-102 targets HDAC2 , while (S)-HDAC-IN-102 ( HY-185554A ) targets HDAC8 . HDAC-IN-102 exerts antioxidant effects via scavenging DPPH free radicals and can be used in cancer-related research.
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