PF-04475270

Overview

PF-04475270 is a prodrug of CP-734432 ( HY-119236 ), as well as an agonist of the EP4 prostaglandin receptor , with IC 50 values of 2 nM and 8 nM against human and canine sources, respectively. PF-04475270 is rapidly hydrolyzed into its active metabolite CP-734432 by ocular esterases or corneal homogenate, stimulates cAMP production, and activates cAMP response element-mediated β-lactamase activity in cells expressing EP4. PF-04475270 can be used in research related to glaucoma.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Glaucoma | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Prostaglandin Receptor

Product Information

• Catalog No.: HY-185643
• CAS No.: 1201925-19-0
• Molecular Formula: C26H32F3NO4S
• Molecular Weight: 511.60
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source