UNC11676A is an MDA5 ATPase inhibitor with IC 50 values of 6 μM, 115 μM and 108 μM against MDA5 , LGP2 and DDX1 , respectively. MDA5, LGP2 and DDX1 are three human DExD/H-box RNA helicases. UNC11676A can be used in the research of Aicardi-Goutières syndrome, Singleton-Merten syndrome, systemic lupus erythematosus and Alzheimer's disease.
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