TMEM175 agonist 3 (Compound 123) is a TMEM175 agonist, with an EC 50 of 0.044 μM in human TMEM175 FLIPR assays and an EC 50 of 0.073 μM in human TMEM175 EP assays. TMEM175 agonist 3 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases.
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