A-582941

Overview

A-582941 is a selective, orally active, blood-brain barrier-permeable α7 nAChR agonist, with K i values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 exhibits agonistic activity at 5-HT3 receptors, with a K i of 150 nM. A-582941 triggers phosphorylation of ERK1/2 and CREB , inhibits GSK-3β via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos , activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 is applicable for the research of Alzheimer's disease and schizophrenia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Schizophrenia | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > nAChR | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-59201
• CAS No.: 848591-89-9
• Molecular Formula: C17H20N4
• Molecular Weight: 280.38
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source