Glycybridin C is a Protein tyrosine phosphatase 1B ( PTP1B ) inhibitor and pregnane X receptor ( PXR ) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS ( HY-D1056 )-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma.
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