4’-Phosphopantetheine

Overview

4’-Phosphopantetheine is an orally active coenzyme A (CoA) precursor. 4’-Phosphopantetheine is membrane-permeable and acts as a CoA precursor, a prosthetic group, and a reactive oxygen species ( ROS ) inhibitor. 4’-Phosphopantetheine binds covalently to rat liver fatty acid synthase , modifies the conserved serine residue in the PKS / NRPS carrier protein domain, and serves as a substrate for CoA synthase and PPAT . 4’-Phosphopantetheine undergoes non-catalytic exchange on rat liver fatty acid synthase , with a faster turnover rate than that of the enzyme complex, and restores intracellular CoA levels in cells with impaired de novo biosynthesis. 4’-Phosphopantetheine rescues phenotypes induced by CoA deficiency, normalizes PKAN -related biomarkers, restores mitochondrial enzyme activity, and alleviates vascular endothelial damage. 4’-Phosphopantetheine shows biological stability in serum, acts as a prosthetic group and degradation product of ACP , and inhibits the formation of atherosclerotic plaques. 4’-Phosphopantetheine can be used in the research of brain iron accumulation neurodegenerative diseases, pantothenate kinase-associated neurodegeneration, CoASY protein-associated neurodegenerative diseases, coronary heart disease, and atherosclerosis.

Application

Products | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Atherosclerosis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-W1143867
• CAS No.: 2226-71-3
• Molecular Formula: C11H23N2O7PS
• Molecular Weight: 358.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source