Prodelphinidin B3 is a proanthocyanidin compound that exhibits significant anti-tumor activity. Prodelphinidin B3 induces cell cycle arrest at the G1/G0 phase in PC-3 cells, activates caspase-3 , and promotes apoptosis . Prodelphinidin B3 can induce the differentiation of leukemia cells and synergistically enhance retinoic acid ( HY-14649 )-induced granulocytic differentiation and sodium butyrate ( HY-B0350A )-induced monocytic differentiation in HL-60 cells. Prodelphinidin B3 also possesses antioxidant activity. Prodelphinidin B3 is used in research on prostate cancer and leukemia.
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