Gemcitabine 5'-diphosphate

Overview

Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine ( HY-17026 ) and a potent ribonucleotide reductase ( RNR ) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-W791041
• CAS No.: 116371-66-5
• Molecular Formula: C9H13F2N3O10P2
• Molecular Weight: 423.16
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source