Tofersen

Overview

Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC 50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15 , and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Amyotrophic Lateral Sclerosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > SOD

Product Information

• Catalog No.: HY-132580
• CAS No.: 2088232-70-4
• Molecular Formula: C230H317N72O123P19S15
• Molecular Weight: 7128.00
• Purity: 96.53%
• Storage: -20°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: 100 mg/mL (14.03 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source