Topotecan hydrochloride

Overview

Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Topoisomerase

Product Information

• Catalog No.: B0084-055461
• CAS No.: 119413-54-6
• Molecular Formula: C23H24ClN3O5
• Molecular Weight: 457.91
• Purity: >98%
• Storage: Store at 2-8°C
• Solubility: Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated), Water (Slightly, Heated)

Source

Original product source