Flavopiridol Hydrochloride

Overview

Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | CDK

Product Information

• Catalog No.: B0084-083124
• CAS No.: 131740-09-5
• Molecular Formula: C21H20ClNO5.HCl
• Molecular Weight: 438.3
• Purity: >98%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
• Solubility: In Vitro : H2O : ≥ 20 mg/mL(45.63 mM) DMF : 7.69 mg/mL(17.55 mM;Need ultrasonic)

Source

Original product source