Colchicine

Overview

Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. Source summary: Colchicine is a microtubule inhibitor adapted as an ADC cytotoxin for mitotic arrest and apoptosis in antibody-targeted cancer therapy.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Neurological Disease | Microtubule/Tubulin

Product Information

• Catalog No.: B0084-293455
• CAS No.: 64-86-8
• Molecular Formula: C22H25NO6
• Molecular Weight: 399.44
• Purity: >98%
• Storage: Tightly closed. Dry. Keep in a well-ventilated place. Light sensitive.
• Solubility: Slightly soluble in Chloroform, Methanol

Source

Original product source