Nutlin-3a

Overview

Nutlin-3a is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | MDM-2, p53

Product Information

• Catalog No.: B0084-425358
• CAS No.: 675576-98-4
• Molecular Formula: C30H30Cl2N4O4
• Molecular Weight: 581.5
• Purity: 95%
• Storage: - 20 °C
• Solubility: Soluble in DMSO (5 mg/mL)

Source

Original product source