PNU-159682

Overview

PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes. It is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity, and shows >3,000-fold cytotoxic than its parent compound (MMDX and doxorubicin). It is a more potent and well tolerated ADC cytotoxin than doxorubicin. Source summary: PNU-159682, a DNA-intercalating ADC payload, exerts potent cytotoxicity by blocking replication in cancer-targeted applications.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Topoisomerase

Product Information

• Catalog No.: B0238-464295
• CAS No.: 202350-68-3
• Molecular Formula: C32H35NO13
• Molecular Weight: 641.62
• Purity: ≥97%
• Storage: Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
• Solubility: Soluble in DMSO, chloroform (slightly), methanol (slightly)

Source

Original product source