AMI-1

Overview

AMI-1 is a cell-permeable inhibitor which inhibits protein arginine N-methyltransferase (PRMT) activity with IC50 of 8.81 µM for PRMT1 and IC50 of 3.04 µM for Hmt1p in vitro. MI-1 does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site and exhibits minimal effects on both SET (Sub39H1, Suv39H2, SET7) and non-SET (DOT1) lysine N-methyltransferases. Furthermore, AMI-1 prevents in vivo arginine methylation of cellular proteins and can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, thus operating as a brake on certain hormone actions.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | HMTase

Product Information

• Catalog No.: B2693-087022
• CAS No.: 20324-87-2
• Molecular Formula: C21H14N2Na2O9S2
• Molecular Weight: 548.45
• Purity: ≥98%
• Storage: Store at RT
• Solubility: Soluble in DMSO, Ethanol, Water

Source

Original product source