UNC-2025

Overview

UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | FLT3

Product Information

• Catalog No.: B2693-462616
• CAS No.: 1429881-91-3
• Molecular Formula: C28H40N6O
• Molecular Weight: 476.66
• Purity: ≥95%
• Storage: Store at -20°C
• Solubility: Soluble in DMSO, Ethanol, Water

Source

Original product source