Solamargine

Overview

Solamargine is a steroidal alkaloid glycoside extracted from Solanum nigrum (black nightshade). It exhibits potent antitumor activity across multiple cancer types including hepatocellular carcinoma, cholangiocarcinoma, cervical cancer, lung cancer, melanoma, and osteosarcoma. Solamargine induces apoptosis through the mitochondrial pathway by altering mitochondrial membrane potential, upregulating Bax and cleaved caspase-3, and downregulating Bcl-2. It also triggers ferroptosis via ROS accumulation, iron overload, and lipid peroxidation through downregulation of SLC7A11, GPX4, and Nrf2. Additionally, solamargine inhibits cancer cell migration and invasion by blocking the CXCL3-mediated Erk signaling pathway, suppressing EMT, and downregulating MMP-2 and MMP-9. It enhances sensitivity to chemotherapeutic drugs and has shown efficacy in both in vitro and in vivo tumor models. Source summary: Order Solamargine, a glycoalkaloid used in biochemical research and analysis; supplied with high purity for your laboratory needs. Buy now for prompt delivery.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Bcl-2 Family

Product Information

• Catalog No.: B2703-002779
• CAS No.: 20311-51-7
• Molecular Formula: C45H73NO15
• Molecular Weight: 868.06
• Purity: >98%
• Storage: Store in a cool and dry place and at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
• Solubility: Soluble in DMSO

Source

Original product source