KDM5A-IN-1

Overview

KDM5A-IN-1 is a potent, orally bioavailable pan- histone lysine demethylases 5 ( KDM5 ) inhibitor with IC 50 s of 45 nM, 56 nM and 55 nM for KDM5A , KDM5B and KDM5C , respectively, and with an EC 50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Demethylase

Product Information

• Catalog No.: HY-100014
• CAS No.: 1905481-36-8
• Molecular Formula: C15H22N4O2
• Molecular Weight: 290.36
• Purity: 99.64%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.75 mg/mL (9.47 mM); Clear solution
• Availability: In-stock

Source

Original product source