BMY 28674

Overview

BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone ( HY-B1115A ) and is metabolized by CYP3A4 .4 . BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe ( EC 50 s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors ( IC 50 s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-100057
• CAS No.: 125481-61-0
• Molecular Formula: C21H31N5O3
• Molecular Weight: 401.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source