PAP-1

Overview

PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker ( EC 50 =2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 ( EC 50 =45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects.

Application

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Product Information

• Catalog No.: HY-10015
• CAS No.: 870653-45-5
• Molecular Formula: C21H18O5
• Molecular Weight: 350.36
• Purity: 99.75%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (7.14 mM); Clear solution
• Availability: In-stock

Source

Original product source