PF 477736

Overview

PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1 , with a K i of 0.49 nM, it is also a Chk2 inhibitor, with a K i of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2 , Fms , Yes , Aurora-A , FGFR3 , Flt3 , and Ret ( IC 50 =8 (K i ), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.

Application

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Product Information

• Catalog No.: HY-10032
• CAS No.: 952021-60-2
• Molecular Formula: C22H25N7O2
• Molecular Weight: 419.48
• Purity: 99.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution
• Availability: In-stock

Source

Original product source