MELK-8a

Overview

MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase ( MELK ) inhibitor with IC 50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC 50 s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Obesity | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > MELK | Products > Signaling Pathways > Haspin Kinase

Product Information

• Catalog No.: HY-100368
• CAS No.: 1922153-17-0
• Molecular Formula: C25H32N6O
• Molecular Weight: 432.56
• Purity: 98.32%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source