MRK-016

Overview

MRK-016 is a selective, orally bioavailable inverse agonist of GABA A α5 receptor , with an EC 50 of 3 nM for GABA A α5, and K i s of 0.83, 0.85, 0.77 and 1.4 nM for human GABA A α1β3γ2, GABA A α2β3γ2, GABA A α3β3γ2, and GABA A α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.

Application

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Product Information

• Catalog No.: HY-100370
• CAS No.: 342652-67-9
• Molecular Formula: C17H20N8O2
• Molecular Weight: 368.39
• Purity: 99.71%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.75 mg/mL (7.46 mM); Clear solution
• Availability: In-stock

Source

Original product source