SHP099

Overview

SHP099 is an allosteric SHP2 inhibitor, with IC 50 s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2 , SHP2 D61Y , SHP2E69K, SHP2 A72V , SHP2 E76K . SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC 50 : 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > Phosphatase

Product Information

• Catalog No.: HY-100388
• CAS No.: 1801747-42-1
• Molecular Formula: C16H19Cl2N5
• Molecular Weight: 352.26
• Purity: 99.81%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.2 mg/mL (3.41 mM); Clear solution
• Availability: In-stock

Source

Original product source