Cl-amidine hydrochloride

Overview

Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC 50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

Application

Products | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Protein Arginine Deiminase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MicroRNA

Product Information

• Catalog No.: HY-100574A
• CAS No.: 1373232-26-8
• Molecular Formula: C14H20Cl2N4O2
• Molecular Weight: 347.24
• Purity: 99.82%
• Storage: -20°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: ≥ 1.25 mg/mL (3.60 mM); Clear solution
• Availability: In-stock

Source

Original product source