Cl-amidine TFA

Overview

Cl-amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC 50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine TFA induces apoptosis in cancer cells. Cl-amidine TFA induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine TFA prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Signaling Pathways > Protein Arginine Deiminase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MicroRNA

Product Information

• Catalog No.: HY-100574B
• CAS No.: 1043444-18-3
• Molecular Formula: C16H20ClF3N4O4
• Molecular Weight: 424.80
• Purity: 98.10%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 0.67 mg/mL (1.58 mM); Clear solution
• Availability: In-stock

Source

Original product source