Lesogaberan napadisylate

Overview

Lesogaberan (AZD-3355) napadisylate is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptors. The affinity ( K i s) of Lesogaberan napadisylate for rat GABA B and GABA A receptors, as measured by displacement of [ 3 H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan napadisylate inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > GABA Receptor

Product Information

• Catalog No.: HY-10061A
• CAS No.: 477956-38-0
• Molecular Formula: C13H17FNO5PS
• Molecular Weight: 349.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source