Lesogaberan hydrochloride

Overview

Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and GABA A receptors, as measured by displacement of [ 3 H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan hydrochloride inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.

Application

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Product Information

• Catalog No.: HY-10061B
• CAS No.: 2925644-17-1
• Molecular Formula: C3H10ClFNO2P
• Molecular Weight: 177.54
• Purity: 98.0%
• Storage: 4°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: ≥ 6 mg/mL (33.80 mM); Clear solution
• Availability: In-stock

Source

Original product source