MS-444

Overview

MS-444 (BE-34776) is a HuR ( ELAVL1 ) inhibitor that blocks the cytoplasmic translocation of HuR and inhibits its dimerization. MS-444 reduces cytoplasmic HuR levels by preventing the binding of HuR to ARE-mRNA , without altering the total expression of HuR . MS-444 induces apoptosis , inhibits cell growth, angiogenesis and invasion, and also regulates immune function and microbiota. MS-444 effectively alters the number, size and invasiveness of tumors in various cancer models. MS-444 is tolerable to intraperitoneal injection in vivo and can be applied to research related to colorectal cancer , familial adenomatous polyposis, colitis-associated cancer and glioblastoma.

Application

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Product Information

• Catalog No.: HY-100685
• CAS No.: 150045-18-4
• Molecular Formula: C13H10O4
• Molecular Weight: 230.22
• Purity: 98.75%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: 2 mg/mL (8.69 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source