BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with K i s of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage.
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